To assess a hypotensive activity ofnebivolol (nebilet)
including its action on the 24-h profile and baroreceptorcontrol of
arterial pressure (AP), vegetative regulation of the heart andvasculomotor
endothelial function in AP patients, 30 AH patients were givennebivolol in a dose 5 mg/day for 8 weeks. The
results of the treatment show thatnebivolol
effectively maintains a safe 24-h control of AP, acts positively onchronostructure of AP 24-h profile, produced no
clinically significant sideeffects, corrects
vegetative heart regulation and improves baroreceptor
APcontrol. Moreover, nebilet
modulates a stable vasodilating effect which improvesfunction of vascular endothelium, initiates
regression of left ventricularmyocardium
hypertrophy by raising its elasticity without changing much itscontractile function. Thus, nebivolol
is a highly effective drug for treatmentof
arterial hypertension which corrects a wide spectrum of unfavourable
shiftsin cardiovascular system function.
PMID: 14520947 [PubMed - inproce